Figure Q16-18 shows the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood-vessel wall. Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine?
(a) a smooth muscle cell that has a defect in guanylyl cyclase such that it cannot bind NO
(b) a muscle cell that has a defect in guanylyl cyclase such that it constitutively converts GTP to cyclic GMP
(c) a muscle cell that has cyclic GMP phosphodiesterase constitutively active
(d) a drug that blocks an enzyme involved in the metabolic pathway from arginine to NO
Answer:
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